2/12/2024 0 Comments Stem cell transplant donorsSome patients who receive unrelated donor transplants have a partially HLA matched donor. The best available donor may match some or all of your HLA markers. This search will look for the best matched donor or umbilical cord blood unit. If you need an unrelated donor, your primary doctor will enter your HLA data into a computer that searches the data bank of the National Marrow Donor Program (NMDP) and some other registries. Unfortunately, 7 out of 10 of patients who need a transplant don't find a matching donor in their family. Your doctor will want to test your brothers and sisters too. So each brother and sister with the same parents as you has a 1 in 4 chance of matching you. You inherit half of your HLA markers from your mother and half from your father. Your immune system uses these proteins as markers to recognize which cells belong in your body and which do not. HLA are proteins found on most cells in your body. To look for a donor, your doctor will take a blood sample to test for your human leukocyte antigen ( HLA) type. How does the search for a matched donor get started?Ī well-matched donor is important to the success of your transplant. And it can take a long time to find a matched unrelated donor if no related donor is available. Only about 3 out of every 10 people can find a matched related donor. If your doctor thinks you may be a candidate for a bone marrow/stem cell transplant in the future, start looking for a donor right away. In rare cases, temporary anemia and low platelet counts may occur after a person donates stem cells by apheresis.When should I start looking for a suitable donor? ![]() Your bone marrow will make new stem cells to replace the ones you donated. Most people can return to work in about 1 week. You can expect to be sore in your lower back for a few weeks. If stem cells were taken from your bone marrow, you will probably stay in the hospital for 6 to 8 hours. If the donation needs to be repeated and a catheter is used, you may need to stay overnight in the hospital. If stem cells were taken from your blood, you can go home after the donation and resume your normal activities. This is a surgical procedure done under a local or general anesthetic. If a bone marrow collection is done, the marrow is usually removed from the back of your pelvic bone using a special hollow needle. It depends on how many stem cells are needed. The donation may need to be repeated the next day. It's not unusual to feel light-headed, have chills, feel numbness around your lips, or have cramping in your hands during the donation. Exclusions for stem cell donation Certain infectious diseases, such as hepatitis or HIV Cancer Severe arthritis, including rheumatoid arthritis Severe. You won't be able to move around during that time. If the veins in your arm won't work, the doctor may put a catheter in your neck or chest instead. Then your blood is sent back into you through a needle in your other arm. Your blood is sent through a machine that takes out the stem cells and saves them. A nurse will stick a needle into a vein in your arm to take your blood. During the donationĭonations are done in a blood centre or hospital. These side effects usually go away 2 or 3 days later. The medicine in the shots may cause bone and muscle aches, headaches, fatigue, and trouble sleeping. Before the donationįor 4 or 5 days before you donate, you will get shots to help your bone marrow make and send more stem cells into your bloodstream. ![]() Stem cells can also be collected from your bone marrow. How it's doneĬollecting or harvesting stem cells from your bloodstream is called apheresis. And you'll be asked to sign a consent form to have the procedure. You will also be asked questions about your health and your family history of diseases. If you are chosen as a stem cell donor, you will have a complete physical examination. This is to see if your tissue type matches well enough for the transplant. If a match is found, another blood sample will be taken. It's then compared with the tissue types of people who need a transplant. If you wish to be a stem cell donor, a blood sample is taken from you and tested for tissue type. Healthy adults ages 17 to 35 can register to donate stem cells.
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